The nanoDNAsequencing project aims to investigate a
novel single-molecule DNA sequencing nanotechnology protocol (gene
sequencer) that has potential to sequence a molecule of genomic dimensions
in hours without expensive and fault sensitive DNA copying steps and
The gene sequencer is based on the electrical
characterization of individual nucleobases, while DNA passes through a
nanopore with integrated nanotube side-electrodes.
The research proposed here will provide a unique
combination of state of the art capabilities for cutting and usage of
single wall carbon nanotubes as electrodes forming a lithographically
fabricated “nanogap” with single-nanometer precision.
In addition, the synergy of consortium resources for
electrical characterization and leading theoretical skills for
nanotransport will provide new solutions and information for an answer on
the proof-of-principle question: is it possible to detect different types
of DNA bases by their electrical properties?